About Bravo

This variant browser currently shows chromosome locations, alleles, VEP functional annotations, and allele frequencies for 463 million variants observed in 62,784 individuals sequenced in NHLBI's TOPMed program.

The information is shared by TOPMed Phase 1 and Phase 2 studies and is available for users that agree to the terms.

The sequencing analysis pipeline consists of two major processes:

  1. Harmonization of data from the BAM files provided by the sequencing centers and
  2. Joint variant discovery and genotype calling across studies.
The alignment pipeline is available at github.com/statgen/gotcloud.

If you have a question about this website, contact bravo-group@umich.edu.

Developers: Daniel Taliun and Peter VandeHaar

Acknowledgments: ExAC Developers

The NHLBI Trans-Omics for Precision Medicine (TOPMed) Whole Genome Sequencing Program. BRAVO variant browser: University of Michigan and NHLBI; 2018. Available from: https://bravo.sph.umich.edu/freeze5/hg38/